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KMID : 1036420180110020043
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대한치의학회 영문학회지
2018 Volume.11 No. 2 p.43 ~ p.56
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Bone Regeneration Using Block-type Deproteinized Porcine Bone Mineral with Collagen Membrane Using 3,4-Dihydroxyphenylalanine as Bone Adhesive
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Kang Joo-Hyun
Pae Hyoung-Chul
Cha Jae-Kook
Lee Jung-Seok
Paik Jeong-Won
Jung Ui-Won
Choi Seong-Ho
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Abstract
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Purpose: The purpose of this study was to assess the adhesiveness and cytotoxicity of 3, 4-dihydroxyphenylalanine DOPA), and to evaluate the role of collagen membrane with DOPA in the guided bone regeneration.
Materials and Methods: Peel resistance and cell cytotoxicity test were performed. Four defect types in nine rabbit calvaria were randomly allocated: i) control, ii) membrane, iii) deproteinized porcine bone mineral (DPBM) covered by membrane with DOPA, and iv) DPBM covered by membrane with cyanoacrylate. Animals were sacrificed at 2 (n=4) and 8 weeks (n=5) for microcomputed tomography and histomorphometric analysis. DOPA showed low peel resistance but high cell viability.
Result: Cyanoacrylate and DOPA groups showed significantly higher mineralized tissue volume (MTV) compared to control and membrane groups at 2 weeks (P<0.05). At 8 weeks, DOPA group showed the highest MTV.
Significantly higher new bone area was found in DOPA group at 8 weeks (P<0.05). Bone formation increased from 2 to 8
weeks in DOPA group (P<0.05).
Conclusion: DOPA showed high cell viability and in vivo study revealed predictable performance in bone regeneration.
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KEYWORD
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Adhesive , Bone regeneration , Dihydroxyphenyalanine
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